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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG1 All Species: 22.42
Human Site: S524 Identified Species: 44.85
UniProt: P19174 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19174 NP_002651.2 1290 148532 S524 I Y Y S E E T S S D Q G N E D
Chimpanzee Pan troglodytes XP_514650 1630 185027 S864 I Y Y S E E T S S D Q G N E D
Rhesus Macaque Macaca mulatta XP_001087295 1291 148567 S524 I Y Y S E E T S S D Q G N E D
Dog Lupus familis XP_542998 1249 143812 T502 P K E A S G S T E L H S S E K
Cat Felis silvestris
Mouse Mus musculus Q62077 1302 149650 S524 I Y Y S E E T S S D Q G N E D
Rat Rattus norvegicus P10686 1290 148530 S524 I Y Y S E E T S S D Q G N E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q2VRL0 637 72514
Frog Xenopus laevis Q32NH8 758 87399 R70 I S D I E T V R E G H Q S E V
Zebra Danio Brachydanio rerio A5D6R3 784 89362 E96 T E V E C V R E G C Q S E C L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13217 1095 124845 E407 D C A F V S S E Y P V I L S F
Honey Bee Apis mellifera XP_624101 1134 132613 S446 L F Y T D T F S R T Q E N E H
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 H252 W A M G K V N H C R I K S K L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 99.5 93.2 N.A. 95.3 96.9 N.A. N.A. 21.4 21.7 21.8 N.A. 21.4 45.1 N.A. 35.1
Protein Similarity: 100 79 99.7 94.5 N.A. 96.7 98.2 N.A. N.A. 32.4 37.3 36.3 N.A. 40 62 N.A. 50
P-Site Identity: 100 100 100 6.6 N.A. 100 100 N.A. N.A. 0 20 6.6 N.A. 0 33.3 N.A. 0
P-Site Similarity: 100 100 100 33.3 N.A. 100 100 N.A. N.A. 0 26.6 6.6 N.A. 6.6 60 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 9 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 9 0 0 9 0 0 0 9 9 0 0 0 9 0 % C
% Asp: 9 0 9 0 9 0 0 0 0 42 0 0 0 0 42 % D
% Glu: 0 9 9 9 50 42 0 17 17 0 0 9 9 67 0 % E
% Phe: 0 9 0 9 0 0 9 0 0 0 0 0 0 0 9 % F
% Gly: 0 0 0 9 0 9 0 0 9 9 0 42 0 0 0 % G
% His: 0 0 0 0 0 0 0 9 0 0 17 0 0 0 9 % H
% Ile: 50 0 0 9 0 0 0 0 0 0 9 9 0 0 0 % I
% Lys: 0 9 0 0 9 0 0 0 0 0 0 9 0 9 9 % K
% Leu: 9 0 0 0 0 0 0 0 0 9 0 0 9 0 17 % L
% Met: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 9 0 0 0 0 0 50 0 0 % N
% Pro: 9 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 59 9 0 0 0 % Q
% Arg: 0 0 0 0 0 0 9 9 9 9 0 0 0 0 0 % R
% Ser: 0 9 0 42 9 9 17 50 42 0 0 17 25 9 0 % S
% Thr: 9 0 0 9 0 17 42 9 0 9 0 0 0 0 0 % T
% Val: 0 0 9 0 9 17 9 0 0 0 9 0 0 0 9 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 42 50 0 0 0 0 0 9 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _